Rejuran is one of the most searched Korean skin treatments, and if you are planning a trip to Seoul, the first question is practical: can a Rejuran injection fit into one visit, and is it worth it if you only have a few days? Rejuran Healer places purified salmon DNA fragments, called PN (polynucleotides), into the dermis to help the skin repair itself. It is not a filler, and it is not a one-session makeover. The usual plan is a course of about three sessions. This guide covers what one session can and cannot do, how to plan one visit versus three, how much it hurts, how long the bumps last before a flight, how it compares with Juvelook, and what to compare on price. The answers come from Dr. Park Hwonham, Medical Director of Kondae PPEUM Clinic in Seoul and a surgeon trained at Seoul National University Hospital.
Rejuran Healer is made by PharmaResearch in Korea and was first launched in Korea in 2014. When you search “Rejuran”, you also find the Rejuran skincare line: serums, ampoules and toner pads sold in shops. Those are different products. This guide is about the injection given by a doctor in a clinic.
Rejuran in Korea at a glance
- Good for: skin texture, fine lines and firmness of the skin itself, built up gradually
- One trip? A short trip usually fits one session; the full first course needs return visits or follow-up closer to home
- Sessions: usually 3 sessions, at least 3–4 weeks apart, then maintenance every few months; the change is often noticed around the 2nd–3rd session
- Recovery before a flight: small bumps usually settle in about a day; bruises, if any, can last 1–2 weeks, so book early in your stay
- Not for: adding volume or lifting sagging contours
Can Rejuran Be Done in One Trip to Korea?
Yes, you can have a session during one trip, but you cannot complete the usual course in one short trip. At Kondae PPEUM Clinic, Dr. Park usually recommends three sessions at least three to four weeks apart, followed by maintenance every few months depending on your skin. He bases this on the manufacturer’s guidelines and on what the clinic’s own patients reported in surveys. The sessions need that gap between them, so a week-long holiday has room for one.
What one Rejuran session can and cannot do
- Can: make skin feel more hydrated and smoother. Many people notice that their skin feels softer.
- Usually needs the course: texture and firmness improve more clearly over the first course of about three sessions. Many patients first notice a real change around the second or third session.
- Cannot: add volume, fill hollows or lift sagging contours. Rejuran works on the quality of the skin, not on its shape.
In Dr. Park’s words, doing the first course in a row makes the change much easier to notice than a single session. If you can only come once, it still makes sense, but expect a modest result and treat that session as the start of a course rather than the whole treatment.
Rejuran Korea trip planning: 1 visit vs 3 visits
| Plan | How it works | What to expect |
|---|---|---|
| One session per trip | One session in Seoul, the next on a return trip | Skin may feel smoother after the first session; the clearer change builds as sessions add up |
| Return in 3–4 weeks | Come back three to four weeks later for session two, then again for session three | Follows the usual first-course schedule |
| Start in Seoul, continue at home | First session in Seoul; the next sessions closer to home | Keep the spacing of at least three to four weeks |
| Longer stay in Korea | If you stay longer than three to four weeks, a second session can fall within the same trip | Ask the clinic to schedule both sessions before you arrive |
| After the first course | Maintenance every few months | Timing depends on your skin |
When to book Rejuran within your stay
- Early in the trip: the small bumps usually settle in about a day, but bruises can last longer. Avoid the day before photos, events or your flight home.
- Together with lifting or laser: if you are also having Ultherapy, Shurink or a laser, Rejuran can usually be done on the same day, as the last step.
- Allow time for numbing: numbing cream stays on for 40 to 60 minutes before the injections start, so do not book a tight slot between other plans.
Kondae PPEUM Clinic is directly connected to Konkuk Univ. Station Exit 1, which makes it easy to fit an appointment into a sightseeing day. If this is your first treatment abroad, our first-time Korean clinic guide covers booking, consultation and aftercare questions.
What Rejuran Healer Changes, and What It Does Not
Patients usually describe their skin after Rejuran as smoother, softer and with more of a glow. The aim is the skin itself: texture, fine lines and firmness. The change builds gradually over a course of sessions. The honest way to think about Rejuran is as a treatment that helps skin recover, not one that transforms your face.
| Rejuran Healer aims to improve | Rejuran Healer does not |
|---|---|
| Rough skin texture | Add volume like a filler |
| Fine lines | Lift sagging contours |
| Firmness of the skin | Fill hollows that come from lost volume |
| How hydrated and soft the skin feels | Give a large change after one session |
How the Rejuran injection works
- Injection: a very fine needle places tiny amounts of PN in the upper dermis, closely spaced across the face.
- Signal: as PN breaks down, it is thought to act on fibroblasts through the adenosine A2A receptor, supporting collagen production and calming inflammation.
- Repair: the skin’s support structure fills in little by little over several weeks.
Much of this mechanism comes from cell and animal studies, so it is a reasonable explanation rather than something proven in detail in human skin.
What the studies show, and how strong the evidence is
- A Korean randomized trial around the eyes (27 participants, three sessions two weeks apart) compared PN injections with non-crosslinked hyaluronic acid on opposite sides of the face. Overall, the scores were similar, and PN improved roughness and pores more. No serious adverse events were reported.
- A 2025 systematic review rated the evidence for PN boosters as low to moderate, because most studies are small and short.
- A 2016 report described efficacy and complications of a long-chain polynucleotide product in five patients, which is a very small group.
In short, the research supports Rejuran as a treatment that can help skin quality, but the studies are not large. Results vary between people, and no one can promise a specific outcome for your skin.
Rejuran Korean skincare vs the Rejuran injection
Rejuran Korean skincare is popular, and travellers often buy the serums in Seoul. That is fine, but the skincare line and the injection are not interchangeable.
| Rejuran Healer injection | Rejuran skincare (serum, ampoule, toner pad) | |
|---|---|---|
| Where it goes | Injected into the dermis by a doctor | Applied on the skin surface |
| Ingredient | PN (longer salmon DNA chains) | Depends on the product, often labelled PDRN |
| What the studies above tested | The injection | Not the skincare products |
PN vs PDRN: both are DNA fragments purified from salmon. PDRN fragments are shorter, and PN chains are longer. PN is the form used in Rejuran Healer injections. A “Rejuran PDRN serum” at home is therefore a different product from the clinic treatment, and everything in this guide about results refers to the injection.
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Does the Rejuran Injection Hurt? Pain and Numbing
Yes, Rejuran hurts more than most skin boosters. The treatment uses many tiny injections across the whole face, and thin areas such as the forehead and the skin around the eyes and mouth are the most sensitive. Dr. Park says this openly in consultation, because knowing what to expect makes the session easier.
At Kondae PPEUM Clinic, these options are used to make it more comfortable:
- Numbing cream: left on for 40 to 60 minutes, and injections start only after it has had enough time to work.
- Injector device: sometimes used, a machine designed to make the injections less painful.
- Sedation: suggested for patients who are very afraid of pain.
If you are anxious about pain, say so when you book. That way the clinic can plan the numbing time or discuss sedation before your appointment day rather than on it.
Bumps, Bruising and Flying Home After Rejuran
Right after a Rejuran injection, the skin shows small raised bumps where the product was placed. For a traveller, the key question is how long they last before you board a plane or take photos.
| Reaction | Usually lasts |
|---|---|
| Small raised bumps at injection points | About a day; thin or easily swollen skin can take a little longer |
| Redness and swelling | Hours to a few days |
| Bruising | 1–2 weeks, if it happens |
Before
After a courseRecovery timeline for your trip
| Time | What usually happens |
|---|---|
| Same day | Bumps at injection points, redness, swelling |
| 1–2 days | Some people look back to normal |
| 2–3 days | Makeup once the injection points no longer feel irritated; be careful until then |
| 1–2 weeks | Any bruising fades |
The practical rule for a trip: do not book Rejuran for the day before your flight home, an event or planned photos. Bumps alone usually go down within a day, but a bruise can still be visible for one to two weeks, and you cannot know in advance whether you will bruise. Scheduling the session early in your stay gives you the most room.
Side effects and who should tell the clinic first
Common reactions are the bumps, redness, swelling and bruising described above. Infection, firm nodules and allergic reactions are rare, but every treatment carries some risk. If swelling or pain lasts, tell the clinic straight away; when you are back home, send a message rather than waiting.
- You are allergic to fish or salmon
- You have inflammation or a skin condition in the area to be treated
- You are pregnant or breastfeeding
- You take medicine that makes you bleed easily
Recovery and session timeline
- Treatment dayNumbing cream first; small raised bumps where the injections went
- About 1 dayBumps usually settle (a little longer for thin or easily swollen skin)
- 2–3 daysGo easy on make-up over the injection points
- 1–2 weeksAny bruise fades
- Every 3–4 weeksNext session; about 3 in the first course, then maintenance every few months
DR.BAQUO's Answers on the Rejuran Injection
These are the answers Dr. Park Hwonham, Medical Director of Kondae PPEUM Clinic, gave in his review in November 2026 to the questions travellers ask most about Rejuran.
How many Rejuran sessions do I need, and how far apart?
"I usually recommend three sessions at least three to four weeks apart. After that, maintenance every few months depending on your skin. Doing the first course in a row makes the change much easier to notice than a single session. This is based on the manufacturer's guidelines and on what our own patients reported in surveys."
Does Rejuran hurt?
"Honestly, yes. Many tiny injections across the whole face make it a painful treatment, especially on thin skin such as the forehead and around the eyes and mouth. We start after numbing cream has had enough time to work. We leave it on for 40 to 60 minutes, sometimes use an injector device that reduces pain, and for patients who are very afraid of pain we suggest sedation."
How long do the bumps last, and when can I wear makeup?
"The small raised bumps usually go down in about a day; thin or easily swollen skin can take a little longer. A bruise can last one to two weeks. I recommend waiting until the injection points no longer feel irritated, usually being careful for two to three days. Some patients look normal after one or two days, while small bruises occasionally stay for one to two weeks. If the skin feels calm after a day or two, carefully go back to your usual routine."
Can I get Rejuran on the same day as Ultherapy, Shurink or a laser?
"Usually yes. Injections such as Rejuran are generally done last, after lifting or laser treatments. We recommend Rejuran as the final step of the day."
Juvelook vs Rejuran and Other Skin Boosters
Juvelook vs Rejuran is one of the most common comparisons travellers search for. The two are different products with different ingredients, and they are not simply a cheaper or stronger version of each other. This guide is based on director-reviewed material about Rejuran, so we describe the Rejuran side here and leave Juvelook's own details to our separate pages: the Rejuran vs Juvelook comparison and our Juvelook Volume guide with nasolabial fold cases.
- Choose Rejuran for: the skin itself, meaning texture, fine lines and firmness, with a gradual recovery-type change over a course.
- Look elsewhere if: the main concern is lost volume or sagging. Rejuran does not add volume or lift, and a volume or lifting treatment is usually the better fit for that.
- Other PN brands: if price matters most, other brands with the same PN ingredient can be a more affordable alternative. Ask which product is used and how much.
For a wider view of boosters available in Seoul, including PCL-based options such as Gouri, see our skin booster Korea guide. The right choice depends on your skin and goals, which is what the consultation is for.
Rejuran Healer, Rejuran Eye (Rejuran i) or Rejuran S?
| Product | What is different | Used for |
|---|---|---|
| Rejuran Healer | The original | Texture, fine lines and firmness across the face |
| Rejuran Eye | Lower viscosity, spreads in thin skin | Fine lines, friction pigmentation and dark circles under the eyes |
| Rejuran S | Made for scars | Depressed acne scars |
Rejuran Eye's volume effect is temporary. If the area under your eyes looks hollow because volume has been lost, a volume treatment is usually the better fit than Rejuran Eye.
Rejuran with HIFU, Shurink or lasers
Lifting treatments work on contour, and Rejuran works on the skin itself, so many patients combine them in the same visit. Rejuran is done last on the day, after the lifting or laser treatment. For what a HIFU session involves, see our Shurink HIFU case from Seoul.
Which skin booster fits which goal
| Dr. Park's usual first choice | |
|---|---|
| Texture, fine lines, overall skin recovery | Rejuran |
| Dryness | Hyaluronic acid booster |
| Hollows or scars that need more collagen | Juvelook-type booster |
| Pores and oiliness together with fine lines | Skin botox |
Real skin booster cases at Kondae PPEUM Clinic
We do not have Rejuran-only before & after photos to show yet. These are real cases of other skin boosters from our clinic, the volume type (Gouri, HILO WAVE, Juvelook Volume). Rejuran itself works on texture and fine lines, not volume, so if hollows bother you too, these are the options to compare.
Want a change like this case?
Send us this case and Dr. Park's team will tell you whether a similar plan could suit you.
Want a change like this case?
Send us this case and Dr. Park's team will tell you whether a similar plan could suit you.
Rejuran Injection Price in Korea: What to Compare
These are the current standing prices at Kondae PPEUM Clinic. Event prices are not shown here, and prices may change.
| Item | Price |
|---|---|
| Rejuran Healer 2cc | KRW 209,000 |
| Eye Rejuran Healer 1cc | KRW 159,000 |
| Rejuran HB Plus 1cc | KRW 189,000 |
| Rejuran Skin Booster 2cc | KRW 150,000 |
| Rejuran Tone-Up Booster 2cc | KRW 150,000 |
| Pico Toning + Genesis + Rejuran Tone-Up Booster 2cc (iontophoresis) + LED + Modeling, 10 sessions | KRW 990,000 |
Rejuran events in Korea
Kondae PPEUM Clinic regularly updates its events and packages, including first-visit prices and bundles with other treatments. The prices above are standing prices. For the latest Rejuran event prices and conditions, check the packages page.
See current events →The Rejuran Healer injection discussed in this guide is the first two rows. The other Rejuran-line items are separate products on the price list; ask in consultation how they differ and whether they suit your skin. Remember that the usual first course is about three sessions, so budget for the course, not only one visit.
Rejuran prices vary between clinics in Korea because the conditions vary. Compare these on the same basis:
- How many cc are used (full face or a smaller area)
- Whether a sealed, genuine product is opened in front of you
- Whether numbing and soothing care are included
- For event prices, conditions such as first visit only or session limits
FAQ — Rejuran Injection in Korea
Q: What is the Rejuran injection price in Korea?
A: At Kondae PPEUM Clinic, Rejuran Healer 2cc is KRW 209,000 and Eye Rejuran Healer 1cc is KRW 159,000 (standing prices, subject to change). When comparing clinics, check the number of cc, whether a sealed genuine product is opened in front of you, whether numbing and soothing are included, and any event conditions.
Q: What is Rejuran i, and is it good for under the eyes?
A: Rejuran Eye (often searched as Rejuran i) is a lower-viscosity version made for the thin skin around the eyes. It is used for fine lines, friction pigmentation and dark circles. Its volume effect is temporary, so if the under-eye area looks hollow from lost volume, a volume treatment is usually the better fit.
Q: Juvelook vs Rejuran: which should I choose?
A: They are different products with different ingredients. Rejuran uses PN to work on the skin itself (texture, fine lines and firmness) and does not add volume or lift. Which one fits depends on your main concern, which Dr. Park assesses in consultation. Our Rejuran vs Juvelook comparison covers both sides.
Q: How long does Rejuran last?
A: Rejuran results do not last forever, because skin keeps ageing. After the first course of about three sessions, most people continue with maintenance every few months, with the timing depending on their skin.
Q: Is one Rejuran session enough?
A: One session can make skin feel smoother and more hydrated, but texture and firmness usually change more clearly after the first course of three. Many patients first notice a real change around the second or third session.
Q: Do you have Rejuran Korea before and after photos?
A: No. We do not have patient photos for Rejuran, so this page is a treatment guide rather than a case page. Because Rejuran changes skin quality gradually over a course, ask in consultation what change is realistic for your skin.
Q: Is salmon DNA safe if I have a fish allergy?
A: Rejuran uses purified PN and is sold as a medical device product. Studies so far mostly report mild reactions, but they are small and short. If you are allergic to fish or salmon, tell the clinic before treatment.
Related Before & After Cases and Guides
- Skin Booster Before and After Korea — Gouri + HILO WAVE Results
- Hollow Temples Treatment in Korea: Gouri & HILO WAVE Before and After
- Juvelook Volume Before and After: Nasolabial Fold Case in Korea
- Kpop Concert Skin Clinic: Dr. Baquo's Guide to Glowing for Your Seoul Concert Experience
- Gouri PCL Korea: Seoul’s Liquid Collagen Revolution
- Before & After gallery (members)
Sources
- Lampridou S et al. The Effectiveness of Polynucleotides in Esthetic Medicine — A Systematic Review. J Cosmet Dermatol, 2025. PubMed 39645667
- Lee YJ et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation — a randomized, double-blind, split-face trial. J Dermatolog Treat, 2022. PubMed 32248707
- Park KY et al. Long-chain polynucleotide filler for skin rejuvenation — efficacy and complications in five patients. Dermatol Ther, 2016. PubMed 26814448
- Marques C et al. From PDRNs to PNs — Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications. Biomolecules, 2025. PubMed 39858543
This guide is general information, not a diagnosis. Results vary between individuals, and the right plan depends on an in-person consultation. Doctor's answers: Dr. Park Hwonham, Medical Director, Kondae PPEUM Clinic, Seoul, from his review in November 2026.
DR.BAQUO | Hanlim Tower 2F, 229 Achasan-ro, Gwangjin-gu, Seoul | Konkuk University Station Exit 1 (Line 2) | Google Maps | LINE: @364kbfyj | global.drbaquo.com
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Kondae PPEUM Clinic
Dr. Park Hwonham (DR.BAQUO), Medical Director
- Address
- Hanlim Tower 2F, 229 Achasan-ro, Gwangjin-gu, Seoul
- Subway
- Line 2 Konkuk Univ. Station Exit 1 (directly connected)
- Hours
- Mon–Fri 10:00–20:30 · Sat 10:00–16:30 (KST)
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